Higher Lithium Levels Linked to Autism Diagnosis: Experts Call for Further Research.
A recent study published in the journal JAMA Pediatrics has found a moderate association between lithium levels in drinking water and autism spectrum disorder (ASD) diagnosis in Danish children. The researchers analyzed data from 8,842 cases of ASD and 43,864 participants without ASD, finding that exposure to higher levels of lithium during pregnancy was linked to an increased risk of ASD diagnosis.
The study's findings suggest that pregnant women living in areas with higher levels of lithium in drinking water are at a slightly higher risk of having children diagnosed with autism. Specifically, the researchers found that those exposed to the highest levels of lithium had a 46% higher risk of ASD diagnosis compared to those with lower exposure levels.
However, experts caution that the study's results do not necessarily show a direct link between lithium exposure and ASD diagnosis. Dr. Beate Ritz, co-author of the study, emphasized the need for further research to confirm the association and understand its underlying mechanisms.
"The wisdom of Solomon will be required to develop guidelines for lithium in drinking water that are maximally protective of the entire population," said Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School. "Until the basic biology of ASD is better understood, it will be difficult to distinguish causal from spurious associations."
Other researchers have raised concerns about the limitations of the study's findings, pointing out that the association between lithium exposure and ASD diagnosis has not been consistently replicated in other studies.
"We are bombarded with a variety of environmental stressors in our everyday lives," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "We have to figure out how to safely navigate them, and this is probably not one that's high on our list."
The study's findings highlight the need for further research into the potential environmental causes of ASD, but also underscore the complexity of understanding the disorder and its underlying mechanisms.
A recent study published in the journal JAMA Pediatrics has found a moderate association between lithium levels in drinking water and autism spectrum disorder (ASD) diagnosis in Danish children. The researchers analyzed data from 8,842 cases of ASD and 43,864 participants without ASD, finding that exposure to higher levels of lithium during pregnancy was linked to an increased risk of ASD diagnosis.
The study's findings suggest that pregnant women living in areas with higher levels of lithium in drinking water are at a slightly higher risk of having children diagnosed with autism. Specifically, the researchers found that those exposed to the highest levels of lithium had a 46% higher risk of ASD diagnosis compared to those with lower exposure levels.
However, experts caution that the study's results do not necessarily show a direct link between lithium exposure and ASD diagnosis. Dr. Beate Ritz, co-author of the study, emphasized the need for further research to confirm the association and understand its underlying mechanisms.
"The wisdom of Solomon will be required to develop guidelines for lithium in drinking water that are maximally protective of the entire population," said Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School. "Until the basic biology of ASD is better understood, it will be difficult to distinguish causal from spurious associations."
Other researchers have raised concerns about the limitations of the study's findings, pointing out that the association between lithium exposure and ASD diagnosis has not been consistently replicated in other studies.
"We are bombarded with a variety of environmental stressors in our everyday lives," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "We have to figure out how to safely navigate them, and this is probably not one that's high on our list."
The study's findings highlight the need for further research into the potential environmental causes of ASD, but also underscore the complexity of understanding the disorder and its underlying mechanisms.