Researchers studying the potential link between lithium exposure from tap water and autism spectrum disorder (ASD) have found a modestly increased risk of ASD diagnoses among children born to pregnant women exposed to higher levels of lithium.
The study, published in JAMA Pediatrics, looked at data from Denmark and found that as lithium levels in drinking water increased, so did the risk of ASD diagnosis. Specifically, the researchers found that children whose mothers were exposed to high levels of lithium during pregnancy had a 24% to 26% higher risk of ASD diagnosis compared to those with lower exposure levels.
However, experts caution that this association does not necessarily mean that lithium exposure directly causes ASD. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, co-author of the study.
While the findings are intriguing, more research is needed to confirm the link and understand the underlying mechanisms. Ritz noted that further studies are required to look for a similar connection in other countries.
Lithium levels in drinking water vary widely across the US, with some areas having much higher concentrations than others. In Denmark, where this study was conducted, the level of lithium in drinking water is similar to that in American water systems.
The implications of these findings are complex from a public health policy standpoint. On one hand, high levels of lithium in drinking water have been linked to health benefits such as lower rates of hospitalization for psychiatric disorders and suicide. On the other hand, exposure to higher levels of lithium may pose risks to fetal brain development.
Other researchers point out that many environmental exposures, including air pollution and pesticides, have been linked to ASD but do not necessarily prove causation. "There's a lot of speculation about environmental factors, but how many of them are truly causally associated?" said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland.
Ultimately, more research is needed to understand the relationship between lithium exposure and ASD risk. As Dr. Ritz noted, "we have to figure out how to basically safely navigate these stressors" β including potential environmental exposures that may contribute to ASD diagnoses.
The study, published in JAMA Pediatrics, looked at data from Denmark and found that as lithium levels in drinking water increased, so did the risk of ASD diagnosis. Specifically, the researchers found that children whose mothers were exposed to high levels of lithium during pregnancy had a 24% to 26% higher risk of ASD diagnosis compared to those with lower exposure levels.
However, experts caution that this association does not necessarily mean that lithium exposure directly causes ASD. "Any drinking water contaminants that may affect the developing human brain deserve intense scrutiny," said Dr. Beate Ritz, co-author of the study.
While the findings are intriguing, more research is needed to confirm the link and understand the underlying mechanisms. Ritz noted that further studies are required to look for a similar connection in other countries.
Lithium levels in drinking water vary widely across the US, with some areas having much higher concentrations than others. In Denmark, where this study was conducted, the level of lithium in drinking water is similar to that in American water systems.
The implications of these findings are complex from a public health policy standpoint. On one hand, high levels of lithium in drinking water have been linked to health benefits such as lower rates of hospitalization for psychiatric disorders and suicide. On the other hand, exposure to higher levels of lithium may pose risks to fetal brain development.
Other researchers point out that many environmental exposures, including air pollution and pesticides, have been linked to ASD but do not necessarily prove causation. "There's a lot of speculation about environmental factors, but how many of them are truly causally associated?" said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland.
Ultimately, more research is needed to understand the relationship between lithium exposure and ASD risk. As Dr. Ritz noted, "we have to figure out how to basically safely navigate these stressors" β including potential environmental exposures that may contribute to ASD diagnoses.