New Guidance on Statin Side Effects: Most Listed Risks Unsubstantiated
A thorough review of evidence has found that nearly all side effects associated with statins, commonly prescribed to reduce cholesterol levels and lower heart disease risk, are not caused by the medications themselves. This comprehensive assessment of 66 listed side effects, encompassing a vast number of people in 19 randomized controlled trials, reveals that only four potential risks β changes in liver function, minor liver abnormalities, urine changes, and tissue swelling β have strong evidence supporting them.
The review's lead author notes that the results demonstrate statins do not significantly contribute to memory problems, depression, sleep disturbances, or nerve damage leading to tingling sensations. In fact, the study found that patients taking statins experienced these side effects at a similar rate as those not on the medication.
While it is acknowledged that some individuals may experience side effects while using statins, especially after extended periods of use beyond the trial duration, this comprehensive analysis reassures many that the benefits far outweigh the risks. The researchers' findings are seen as a valuable counter to misinformation surrounding statins and aim to provide patients and doctors with more accurate information.
As a result, experts recommend updating statin labels to better reflect the evidence, allowing for more informed decisions about whether or not to use these life-saving medications. The British Heart Foundation, which partly funded this research, views it as a significant step toward addressing unnecessary concerns surrounding statins and preventing avoidable cardiovascular deaths.
A thorough review of evidence has found that nearly all side effects associated with statins, commonly prescribed to reduce cholesterol levels and lower heart disease risk, are not caused by the medications themselves. This comprehensive assessment of 66 listed side effects, encompassing a vast number of people in 19 randomized controlled trials, reveals that only four potential risks β changes in liver function, minor liver abnormalities, urine changes, and tissue swelling β have strong evidence supporting them.
The review's lead author notes that the results demonstrate statins do not significantly contribute to memory problems, depression, sleep disturbances, or nerve damage leading to tingling sensations. In fact, the study found that patients taking statins experienced these side effects at a similar rate as those not on the medication.
While it is acknowledged that some individuals may experience side effects while using statins, especially after extended periods of use beyond the trial duration, this comprehensive analysis reassures many that the benefits far outweigh the risks. The researchers' findings are seen as a valuable counter to misinformation surrounding statins and aim to provide patients and doctors with more accurate information.
As a result, experts recommend updating statin labels to better reflect the evidence, allowing for more informed decisions about whether or not to use these life-saving medications. The British Heart Foundation, which partly funded this research, views it as a significant step toward addressing unnecessary concerns surrounding statins and preventing avoidable cardiovascular deaths.